Recent Publications 2022-2023 (Current)

Previous Publications

2024-2025 Publications (Current)

 

  1. Serrano-González J, Montes-Rodríguez I, Renta JY, Rojas R, Cadilla CL. After an initial Hermansky-Pudlak syndrome clinical diagnosis, molecular testing reveals variants for oculocutaneous albinism type 1B: A case report. Mol Genet Genomic Med. 2024 Jul;12(7):e2493. doi: 10.1002/mgg3.2493. PubMed PMID: 38994739; PubMed Central PMCID: PMC11240142.
     
  2. Nuñez-Medina HJ, Monero M, Torres LM, Leal E, Gonzalez-Sepulveda L, Mayor ÁM, Renta JY, González-García ER, González A, Melin K, Scott SA, Ruaño G, Hernandez-Suarez DF, Duconge J. Implementing a pharmacogenomic-driven algorithm to guide antiplatelet therapy among Caribbean Hispanics: a non-randomised clinical trial. BMJ Open. 2024 Sep 5;14(9):e084119. doi: 10.1136/bmjopen-2024-084119. PubMed PMID: 39242160; PubMed Central PMCID: PMC11381646.
     
  3. Vélez-López O, Carrasquillo-Carrión K, Cantres-Rosario YM, Machín-Martínez E, Álvarez-Ríos ME, Roche-Lima A, Tosado-Rodríguez EL, Meléndez LM. Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics. Biomedicines. 2024 Aug 23;12(9):1934. doi: 10.3390/biomedicines12091934. PMID: 39335448; PMCID: PMC11428496.
     
  4. Ontiveros-Ángel P, Vega-Torres JD, Simon TB, Williams V, Inostroza-Nives Y, Alvarado-Crespo N, Gonzalez YV, Pompolius M, Katzka W, Lou J, Sharafeddin F, De la Peña I, Dong T, Gupta A, Viet CT, Febo M, Obenaus A, Nair A, Figueroa JD. Early-life obesogenic environment integrates immunometabolic and epigenetic signatures governing neuroinflammation. Brain Behav Immun Health. 2024 Dec;42:100879. doi: 10.1016/j.bbih.2024.100879. eCollection 2024 Dec. PubMed PMID: 39430879; PubMed Central PMCID: PMC11490928.
     
  5. Caraballo EV, Centeno-Girona H, Torres-Velásquez BC, Martir-Ocasio MM, González-Pons M, López-Acevedo SN, Cruz-Correa M. Diagnostic Accuracy of a Blood-Based Biomarker Panel for Colorectal Cancer Detection: A Pilot Study. Cancers (Basel). 2024 Dec 15;16(24). doi: 10.3390/cancers16244176. PubMed PMID: 39766076; PubMed Central PMCID: PMC11674677.
     
  6. Godoy-Vitorino F. Solutions to expand microbiome sciences in the Caribbean Region: an insider's perspective. Trends Microbiol. 2025 Jan 8;. doi: 10.1016/j.tim.2024.12.005. [Epub ahead of print] PubMed PMID: 39788811; NIHMSID:NIHMS2042751.
     
  7. Ebersole JL, Novak MJ, Cappelli D, Dawson DR 3rd, Gonzalez OA. Use of Nonhuman Primates in Periodontal Disease Research: Contribution of the Caribbean Primate Research Center and Cayo Santiago Rhesus Colony. Am J Primatol. 2025 Feb;87(2):e23724. doi: 10.1002/ajp.23724. Review. PubMed PMID: 39902755.
     
  8. Musicaro RM, Valdespino-Hayden Z, Lozano MM, Ramos CN, Joshipura K, Lowe SR. Pre-disaster Health Vulnerabilities Predict Major Depressive Disorder Symptoms Among High-Risk Puerto Rican Adults after Hurricanes Maria and Irma. Disaster Med Public Health Prep. 2025 Feb 6;19:e22. doi: 10.1017/dmp.2024.169. PubMed PMID: 39911054.
     
  9. Meléndez-Vázquez NM, Nguyen TT, Fan X, López-Rivas AR, Fueyo J, Gomez-Manzano C, Godoy-Vitorino F. Gut microbiota composition is associated with the efficacy of Delta-24-RGDOX in malignant gliomas. Mol Ther Oncol. 2024 Mar 21;32(1):200787. doi: 10.1016/j.omton.2024.200787. eCollection 2024 Mar 21. PubMed PMID: 38596290; PubMed Central PMCID: PMC10951704.
     
  10. Rosario-Rodríguez LJ, Cantres-Rosario YM, Carrasquillo-Carrión K, Rodríguez-De Jesús AE, Cartagena-Isern LJ, García-Requena LA, Roche-Lima A, Meléndez LM. Quantitative Proteomics Reveal That CB2R Agonist JWH-133 Downregulates NF-κB Activation, Oxidative Stress, and Lysosomal Exocytosis from HIV-Infected Macrophages. Int J Mol Sci. 2024 Mar 13;25(6):3246. doi: 10.3390/ijms25063246. PMID: 38542221; PMCID: PMC10970132.
     
  11. Tosado-Rodríguez E, Alvarado-Vélez I, Romaguera J, Godoy-Vitorino F. Vaginal Microbiota and HPV in Latin America: A Narrative Review. Microorganisms. 2024 Mar 20;12(3). doi: 10.3390/microorganisms12030619. Review. PubMed PMID: 38543670; PubMed Central PMCID: PMC10974203.
     
  12. Roche-Lima A, Rosado-Quiñones AM, Feliu-Maldonado RA, Figueroa-Gispert MDM, Díaz-Rivera J, Díaz-González RG, Carrasquillo-Carrion K, Nieves BG, Colón-Lorenzo EE, Serrano AE. Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred©) tool. Acta Parasitol. 2024 Mar;69(1):415-425. doi: 10.1007/s11686-023-00765-z. Epub 2024 Jan 2. PubMed PMID: 38165555; PubMed Central PMCID: PMC11001753.
     
  13. Rogozin IB, Saura A, Poliakov E, Bykova A, Roche-Lima A, Pavlov YI, Yurchenko V. Properties and Mechanisms of Deletions, Insertions, and Substitutions in the Evolutionary History of SARS-CoV-2. Int J Mol Sci. 2024 Mar 26;25(7). doi: 10.3390/ijms25073696. Review. PubMed PMID: 38612505; PubMed Central PMCID: PMC11011937.
     
  14. Rodríguez-Morales R. Sensing in the dark: Constructive evolution of the lateral line system in blind populations of Astyanax mexicanus. Ecol Evol. 2024 Apr;14(4):e11286. doi: 10.1002/ece3.11286. eCollection 2024 Apr. Review. PubMed PMID: 38654714; PubMed Central PMCID: PMC11036076.
     
  15. Jirau-Colón H, Jiménez-Vélez BD. PM(2.5) Extracts Induce INFγ-Independent Activation of CIITA, MHCII, and Increases Inflammation in Human Bronchial Epithelium. Toxics. 2024 Apr 16;12(4). doi: 10.3390/toxics12040292. PubMed PMID: 38668515; PubMed Central PMCID: PMC11054084.
     
  16. Rosario-Rodríguez LJ, Cantres-Rosario YM, Carrasquillo-Carrión K, Rosa-Díaz A, Rodríguez-De Jesús AE, Rivera-Nieves V, Tosado-Rodríguez EL, Méndez LB, Roche-Lima A, Bertrán J, Meléndez LM. Plasma Proteins Associated with COVID-19 Severity in Puerto Rico. Int J Mol Sci. 2024 May 16;25(10). doi: 10.3390/ijms25105426. PubMed PMID: 38791465; PubMed Central PMCID: PMC11121485.
     
  17. Heredia-Negrón F, Tosado-Rodríguez EL, Meléndez-Berrios J, Nieves B, Amaya-Ardila CP, Roche-Lima A. Assessing the Impact of AI Education on Hispanic Healthcare Professionals' Perceptions and Knowledge. Educ Sci (Basel). 2024 Apr;14(4). doi: 10.3390/educsci14040339. Epub 2024 Mar 22. PubMed PMID: 38818527; PubMed Central PMCID: PMC11138866.
     
  18. Díaz-Rivera J, Rodríguez-Rivera MA, Meléndez-Vázquez NM, Godoy-Vitorino F, Dorta-Estremera SM. Immune and Microbial Signatures Associated with PD-1 Blockade Sensitivity in a Preclinical Model for HPV+ Oropharyngeal Cancer. Cancers (Basel). 2024 May 30;16(11):2065. doi: 10.3390/cancers16112065. PMID: 38893183; PMCID: PMC11171047.
     
  19. García-Cortés CG, Parés-Matos EI. New Regulatory roles for Human Serum Amyloid A. Int J Res Oncol. 2024;3(1):3249. Epub 2024 Apr 13. PMID: 39044740; PMCID: PMC11262547.
     
  20. Ruiz-Barrionuevo JM, Kardas E, Rodríguez-Barreras R, Quiñones-Otero MA, Ruiz-Diaz CP, Toledo-Hernández C, Godoy-Vitorino F. Shifts in the gut microbiota of sea urchin Diadema antillarum associated with the 2022 disease outbreak. Front Microbiol. 2024;15:1409729. doi: 10.3389/fmicb.2024.1409729. eCollection 2024 Jul. PubMed PMID: 39135877; PubMed Central PMCID: PMC11317302.
     
  21. LeBien J, Velev J, Roche-Lima A. Indirect reference interval estimation using a convolutional neural network with application to cancer antigen 125. Sci Rep. 2024 Aug 20;14(1):19332. doi: 10.1038/s41598-024-70074-6. PMID: 39164433; PMCID: PMC11336095.
     
  22. Vaasjo LO, Miller MW. A conserved gastropod withdrawal circuit in Biomphalaria glabrata, an intermediate host for schistosomiasis. J Neurophysiol. 2024 May 1;131(5):903-913. doi: 10.1152/jn.00390.2023. Epub 2024 Mar 13. PubMed PMID: 38478883; PubMed Central PMCID: PMC11383391.
     
  23. Acevedo-Román A, Pagán-Zayas N, Velázquez-Rivera LI, Torres-Ventura AC, Godoy-Vitorino F. Insights into Gut Dysbiosis: Inflammatory Diseases, Obesity, and Restoration Approaches. Int J Mol Sci. 2024 Sep 8;25(17). doi: 10.3390/ijms25179715. Review. PubMed PMID: 39273662; PubMed Central PMCID: PMC11396321.
     
  24. Monero-Paredes M, Santiago E, Carrasquillo-Carrion K, Renta JY, Rogozin IB, Roche-Lima A, Duconge J. Paraoxonase-1 as a Cardiovascular Biomarker in Caribbean Hispanic Patients Treated with Clopidogrel: Abundance and Functionality. Int J Mol Sci. 2024 Oct 3;25(19). doi: 10.3390/ijms251910657. PubMed PMID: 39408985; PubMed Central PMCID: PMC11477108.
     
  25. Lloret-Torres ME, Barreto-Estrada JL. LF-DBS of the ventral striatum shortens persistence for morphine place preference and modulates BDNF expression in the hippocampus. Behav Brain Res. 2025 Feb 4;477:115300. doi: 10.1016/j.bbr.2024.115300. Epub 2024 Oct 28. PubMed PMID: 39490421; PubMed Central PMCID: PMC11574767.
     
  26. Meléndez-Vázquez NM, Gomez-Manzano C, Godoy-Vitorino F. Oncolytic Virotherapies and Adjuvant Gut Microbiome Therapeutics to Enhance Efficacy Against Malignant Gliomas. Viruses. 2024 Nov 14;16(11):1775. doi: 10.3390/v16111775. PMID: 39599889; PMCID: PMC11599061.
     
  27. Silva-Torres LA, Mozayani A. Xylazine abuse, the growing risk: A review of its effects, upsurge use and associated fatalities in the USA and Puerto Rico. J Forensic Leg Med. 2024 Nov;108:102780. doi: 10.1016/j.jflm.2024.102780. Epub 2024 Oct 19. Review. PubMed PMID: 39454518; PubMed Central PMCID: PMC11622113.
     
  28. Martínez-Jiménez JE, Sathisaran I, Reyes Figueroa F, Reyes S, López-Nieves M, Vlaar CP, Monbaliu JM, Romañach R, Ruaño G, Stelzer T, Duconge J. A review of precision medicine in developing pharmaceutical products: Perspectives and opportunities. Int J Pharm. 2025 Feb 10;670:125070. doi: 10.1016/j.ijpharm.2024.125070. Epub 2024 Dec 15. Review. PubMed PMID: 39689830; PubMed Central PMCID: PMC11781955.
     
  29. Previdi IL, Vega CV, Otero NH, Guzzi Vasques A, Colón GA, Ayala I, Guilloty N, Medina J, Cancel M, Contreras S, Cordero J, Alshawabkeh A. The Impact of the COVID-19 Pandemic on Pregnancy, Birth Experiences, and Mental Health: Voices from Women in Puerto Rico. Matern Child Health J. 2025 Feb;29(2):139-147. doi: 10.1007/s10995-024-04026-x. Epub 2024 Dec 14. PubMed PMID: 39674860; PubMed Central PMCID: PMC11821663.
     
  30. Rivera A, Bracho-Rincón D, Miller MW. Localization of Cholecystokinin/Sulfakinin Neuropeptides in Biomphalaria glabrata, an Intermediate Host for Schistosomiasis. J Comp Neurol. 2025 Jan;533(1):e70016. doi: 10.1002/cne.70016. PubMed PMID: 39825709; PubMed Central PMCID: PMC11841659.
     
  31. Lafarga Previdi I, Hernández Otero N, Guzzi Vasques A, Ayala I, Alvelo Colón G, Guilloty N, Medina J, Cancel-Garcia M, Cordero J, Alshawabkeh AN, Vélez Vega C. The Impact of COVID-19 on Maternal Health: Quantitative Data Related to Risk and Protective Factors Among Pregnant and Postpartum Women in Puerto Rico. Int J Environ Res Public Health. 2025 Jan 22;22(2). doi: 10.3390/ijerph22020141. PubMed PMID: 40003367; PubMed Central PMCID: PMC11855153.
     
  32. Meadows MC, Serino N, Camacho-Monclova DM, Joshipura K, Lowe SR. Beyond the storms: Exploring predictors of posttraumatic stress and posttraumatic growth among survivors of hurricanes Irma and Maria in Puerto Rico. J Clim Chang Health. 2025 Jan-Feb;21. doi: 10.1016/j.joclim.2024.100365. Epub 2024 Nov 29. PubMed PMID: 40026672; PubMed Central PMCID: PMC11870674.
     
  33. Rosado-Quiñones AM, Colón-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodríguez J, Serrano AE. Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs. Antimicrob Agents Chemother. 2024 Jun 5;68(6):e0164323. doi: 10.1128/aac.01643-23. Epub 2024 Apr 19. PMID: 38639491; PMCID: PMC11620517.