Publications 2014-2015

 Journal Articles

  1. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:138-45. doi: 10.1016/j.jsbmb.2013.11.003. Review. PubMed PMID: 24239505; PubMed Central PMCID: PMC4018438. 

  2. Vallejo D, Habib MR, Delgado N, Vaasjo LO, Croll RP, Miller MW. Localization of tyrosine hydroxylase-like immunoreactivity in the nervous systems of Biomphalaria glabrata and Biomphalaria alexandrina, intermediate hosts for schistosomiasis. J Comp Neurol. 2014 Aug 1;522(11):2532-52. doi: 10.1002/cne.23548. PubMed PMID: 24477836; PubMed Central PMCID: PMC4043854. 

  3. Torres R, Santos E, Orraca L, Elias A, Palacios C. Diet quality, social determinants, and weight status in Puerto Rican children aged 12 years. J Acad Nutr Diet. 2014 Aug;114(8):1230-5. doi: 10.1016/j.jand.2014.01.011. PubMed PMID: 24656710; PubMed Central PMCID: PMC4111983. 

  4. López-López L, Nieves-Plaza M, Castro Mdel R, Font YM, Torres- Ramos CA, Vilá LM, Ayala-Peña S. Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with systemic lupus erythematosus. Lupus. 2014 Oct;23(11):1133- 41. doi: 10.1177/0961203314537697. PubMed PMID: 24899636; PubMed Central PMCID: PMC4156531. 

  5. Palacios C, Martin BR, McCabe GP, McCabe L, Peacock M, Weaver CM. Dietary calcium requirements do not differ between Mexican-American boys and girls. J Nutr. 2014 Aug;144(8):1167- 73. doi: 10.3945/jn.113.188318. PubMed PMID: 24872223; PubMed Central PMCID: PMC4093982. 

  6. Flores-Otero J, Ahn KH, Delgado-Peraza F, Mackie K, Kendall DA, Yudowski GA. Ligand-specific endocytic dwell times control functional selectivity of the cannabinoid receptor 1. Nat Commun. 2014 Aug 1;5:4589. doi: 10.1038/ncomms5589. PubMed PMID: 25081814; PubMed Central PMCID: PMC4227836. 

  7. Zenón F, Segarra AC, Gonzalez M, Meléndez LM. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIVinfected macrophages. J Neuroimmune Pharmacol. 2014 Dec;9(5):703-15. doi: 10.1007/s11481-014-9563-z. PubMed PMID: 25209871; PubMed Central PMCID: PMC4209444. 

  8. Valentín II, Rivera G, Nieves-Plaza M, Cruz I, Renta JY, Cadilla CL, Feliu JF, Seip RL, Ruaño G, Duconge J. Pharmacogenetic association study of warfarin safety endpoints in Puerto Ricans. P R Health Sci J. 2014 Sep;33(3):97-104. PubMed PMID: 25244877; PubMed Central PMCID: PMC4196861. Page Continuation Format Page Program Director/Principal Investigator (Last, First, Middle): Publications, 2014-2015, 

  9. Velásquez-Martínez MC, Vázquez-Torres R, Rojas LV, Sanabria P, Jiménez-Rivera CA. Alpha-1 adrenoreceptors modulate GABA release onto ventral tegmental area dopamine neurons. Neuropharmacology. 2015 Jan;88:110-21. doi: 10.1016/j.neuropharm.2014.09.002. PubMed PMID: 25261018; PubMed Central PMCID: PMC4252518. 

  10. Do-Monte FH, Quiñones-Laracuente K, Quirk GJ. A temporal shift in the circuits mediating retrieval of fear memory. Nature. 2015 Mar 26;519(7544):460-3. doi: 10.1038/nature14030. PubMed PMID: 25600268; PubMed Central PMCID: PMC4376623. 

  11. Gómez-Moreno R, Robledo IE, Baerga-Ortiz A. Direct Detection and Quantification of Bacterial Genes Associated with Inflammation in DNA Isolated from Stool. Adv Microbiol. 2014 Nov;4(15):1065- 1075. PubMed PMID: 25635239; PubMed Central PMCID: PMC4307837. 

  12. Lewis RC, Cantonwine DE, Del Toro LV, Calafat AM, Valentin- Blasini L, Davis MD, Montesano MA, Alshawabkeh AN, Cordero JF, Meeker JD. Distribution and determinants of urinary biomarkers of exposure to organophosphate insecticides in Puerto Rican pregnant women. Sci Total Environ. 2015 Apr 15;512-513:337-44. doi: 10.1016/j.scitotenv.2015.01.059. PubMed PMID: 25634738; PubMed Central PMCID: PMC4339526. 

  13. Gerena Y, Menéndez-Delmestre R, Skolasky RL, Hechavarria RM, Pérez S, Hilera C, González C, Nath A, Wojna V. Soluble insulin receptor as a source of insulin resistance and cognitive impairment in HIV-seropositive women. J Neurovirol. 2015 Apr;21(2):113-9. doi: 10.1007/s13365-014-0310-2. PubMed PMID: 25604495; PubMed Central PMCID: PMC4375025. 

  14. Claudio-Campos K, Duconge J, Cadilla CL, Ruaño G. Pharmacogenetics of drug-metabolizing enzymes in US Hispanics. Drug Metab Pers Ther. 2015 Jun;30(2):87-105. doi: 10.1515/dmdi- 2014-0023. Review. PubMed PMID: 25431893; PubMed Central PMCID: PMC4447600. 

  15. Morales-Vásquez L, Miranda-Avalo EI, Rodríguez-Medina JR, Quiñones-Badillo Y, Marqués-Lespier J, Muñoz-Acabá J, Pastrana R, Pérez-Cardona CM, Yamamura Y, Torres EA. Demographics, clinical characteristics, IFNL3- and IFNL4- polymorphisms in a cohort of hepatitis C patients from Puerto Rico. P R Health Sci J. 2014 Dec;33(4):177-83. PubMed PMID: 25563035; PubMed Central PMCID: PMC4337961. 

  16. González L, Ramos-Trautmann G, Díaz-Luquis GM, Pérez CM, Palacios C. Vitamin D status is inversely associated with obesity in a clinic-based sample in Puerto Rico. Nutr Res. 2015 Apr;35(4):287-93. doi: 10.1016/j.nutres.2015.02.001. PubMed PMID: 25708459; PubMed Central PMCID: PMC4376559. 

  17. Isidro RA, Cruz ML, Isidro AA, Baez A, Arroyo A, González-Marqués WA, González-Keelan C, Torres EA, Appleyard CB. Immunohistochemical expression of SP-NK-1R-EGFR pathway and VDR in colonic inflammation and neoplasia. World J Gastroenterol. 2015 Feb 14;21(6):1749-58. doi: 10.3748/wjg.v21.i6.1749. PubMed PMID: 25684939; PubMed Central PMCID: PMC4323450. 

  18. Rosas OR, Torrado AI, Santiago JM, Rodriguez AE, Salgado IK, Miranda JD. Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regen Res. 2014 Dec 15;9(24):2164-73. doi: 10.4103/1673-5374.147949. PubMed PMID: 25657738; PubMed Central PMCID: PMC4316450. 

  19. Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016/j.yjmcc.2014.10.009. PubMed PMID: 25451170; PubMed Central PMCID: PMC4312194. 

  20. Jang S, Javadov S. Inhibition of JNK aggravates the recovery of rat hearts after global ischemia: the role of mitochondrial JNK. PLoS One. 2014 Nov 25;9(11):e113526. doi: 10.1371/journal.pone.0113526. PubMed PMID: 25423094; PubMed Central PMCID: PMC4244102. 

  21. Lewis RC, Cantonwine DE, Anzalota Del Toro LV, Calafat AM, Valentin-Blasini L, Davis MD, Baker SE, Alshawabkeh AN, Cordero JF, Meeker JD. Urinary biomarkers of exposure to insecticides, herbicides, and one insect repellent among pregnant women in Puerto Rico. Environ Health. 2014 Nov 19;13:97. doi: 10.1186/1476-069X-13-97. PubMed PMID: 25409771; PubMed Central PMCID: PMC4258050. 

  22. Jezzini SH, Reyes-Colón D, Sosa MA. Characterization of a prawn OA/TA receptor in Xenopus oocytes suggests functional selectivity between octopamine and tyramine. PLoS One. 2014 Oct 28;9(10):e111314. doi: 10.1371/journal.pone.0111314. Erratum in: PLoS One. 2015;10(3):e0118326. PubMed PMID: 25350749; PubMed Central PMCID: PMC4211885. 

  23. Martínez T, Vázquez GJ, Aquino EE, Martínez I, Robledo IE. ISEcp1- mediated transposition of blaKPC into the chromosome of a clinical isolate of Acinetobacter baumannii from Puerto Rico. J Med Microbiol. 2014 Dec;63(Pt 12):1644-8. doi: 10.1099/jmm.0.080721-0. PubMed PMID: 25246647; PubMed Central PMCID: PMC4250837. 

  24. Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL. Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents. J Med Chem. 2014 Oct 23;57(20):8496-502. doi: 10.1021/jm500994n. PubMed PMID: 25211597; PubMed Central PMCID: PMC4207553. 

  25. Velázquez-Marrero C, Seale GE, Treistman SN, Martin GE. Large conductance voltage- and Ca2+-gated potassium (BK) channel β4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases. J Biol Chem. 2014 Oct 17;289(42):29261-72. doi: 10.1074/jbc.M114.604306. PubMed PMID: 25190810; PubMed Central PMCID: PMC4200277. 

  26. Pézier A, Jezzini SH, Marie B, Blagburn JM. Engrailed alters the specificity of synaptic connections of Drosophila auditory neurons with the giant fiber. J Neurosci. 2014 Aug 27;34(35):11691-704. doi: 10.1523/JNEUROSCI.1939-14.2014. PubMed PMID: 25164665; PubMed Central PMCID: PMC4145173. 

  27. Ortiz A, Capo-Lugo CE, Venegas-Rios HL. Biomechanical deficiencies in women with semitendinosus-gracilis anterior cruciate ligament reconstruction during drop jumps. PM R. 2014 Dec;6(12):1097-106. doi: 10.1016/j.pmrj.2014.07.003. PubMed PMID: 25043260; PubMed Central PMCID: PMC4268129. 

  28. Nuñez RE, Castro M, Javadov S, Escobales N. Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery. J Cardiovasc Pharmacol. 2014 Aug;64(2):172-9. doi: 10.1097/FJC.0000000000000103. PubMed PMID: 24705171; PubMed Central PMCID: PMC4126876. 

  29. Rodríguez-Cotto RI, Ortiz-Martínez MG, Rivera-Ramírez E, Mateus VL, Amaral BS, Jiménez-Vélez BD, Gioda A. Particle pollution in Rio de Janeiro, Brazil: increase and decrease of pro-inflammatory cytokines IL-6 and IL-8 in human lung cells. Environ Pollut. 2014 Nov;194:112-20. doi: 10.1016/j.envpol.2014.07.010. PubMed PMID: 25106047; PubMed Central PMCID: PMC4448729. 

  30. Rodríguez-Cotto RI, Ortiz-Martínez MG, Jiménez-Vélez BD. Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB. Environ Toxicol Pharmacol. 2015 Mar;39(2):845-56. doi: 10.1016/j.etap.2015.02.015. PubMed PMID: 25769104; PubMed Central PMCID: PMC4447117. 

  31. Barreto-Torres G, Hernandez JS, Jang S, Rodríguez-Muñoz AR, Torres-Ramos CA, Basnakian AG, Javadov S. The beneficial effects of AMP kinase activation against oxidative stress are associated with prevention of PPARα-cyclophilin D interaction in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2015 Apr 1;308(7):H749-58. doi: 10.1152/ajpheart.00414.2014. PubMed PMID: 25617357; PubMed Central PMCID: PMC4385997. 

  32. Vega-Rodríguez J, Pastrana-Mena R, Crespo-Lladó KN, Ortiz JG, Ferrer-Rodríguez I, Serrano AE. Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin. PLoS One. 2015 May 26;10(5):e0128212. doi: 10.1371/journal.pone.0128212. PubMed PMID: 26010448; PubMed Central PMCID: PMC4444287. 

  33. Sierra-Mercado D, McAllister LM, Lee CC, Milad MR, Eskandar EN, Whalen MJ. Controlled cortical impact before or after fear conditioning does not affect fear extinction in mice. Brain Res. 2015 May 5;1606:133-41. doi: 10.1016/j.brainres.2015.02.031. PubMed PMID: 25721797; PubMed Central PMCID: PMC4518729. 

  34. Habib MR, Mohamed AH, Osman GY, Sharaf El-Din AT, Mossalem HS, Delgado N, Torres G, Rolón-Martínez S, Miller MW, Croll RP. Histamine Immunoreactive Elements in the Central and Peripheral Nervous Systems of the Snail, Biomphalaria spp., Intermediate Host for Schistosoma mansoni. PLoS One. 2015 Jun 18;10(6):e0129800. doi: 10.1371/journal.pone.0129800. PubMed PMID: 26086611; PubMed Central PMCID: PMC4472778. 

  35. Claudio-Campos K, Hernández-Rivera J, Rivera-Gutierrez J, Ortiz- Rivera I, Carvajal-Vélez A, Pérez-Torres M, Pagán-Ortiz M, Ospina- Millán CA. Biological screening of select Puerto Rican plants for cytotoxic and antitumor activities. P R Health Sci J. 2015 Mar;34(1):25-30. PubMed PMID: 25856874; PubMed Central PMCID: PMC4586088. 

  36. Roman-Vendrell C, Yudowski GA. Real-time imaging of mu opioid receptors by total internal reflection fluorescence microscopy. Methods Mol Biol. 2015;1230:79-86. doi: 10.1007/978-1-4939- 1708-2_6. PubMed PMID: 25293317; PubMed Central PMCID: PMC4836948. 

  37. West RJ, Lu Y, Marie B, Gao FB, Sweeney ST. Rab8, POSH, and TAK1 regulate synaptic growth in a Drosophila model of frontotemporal dementia. J Cell Biol. 2015 Mar 30;208(7):931-47. doi: 10.1083/jcb.201404066. PubMed PMID: 25800055; PubMed Central PMCID: PMC4384727. 

  38. Rosenthal JJ. The emerging role of RNA editing in plasticity. J Exp Biol. 2015 Jun;218(Pt 12):1812-21. doi: 10.1242/jeb.119065. Review. PubMed PMID: 26085659; PubMed Central PMCID: PMC4487009. 

  39. Díaz-Algorri Y, Lozada ME, López SM, Bertrán-Rodríguez CE, González-Hernández CM, González D, Pérez-Cardona CM, Hernández J, Pedrosa C, Toro DH, González-Pons M, Cruz-Correa M. Type 2 diabetes mellitus and colorectal neoplasia risk in Hispanics: a case-control study. J Diabetes Complications. 2015 May-Jun;29(4):502-7. doi: 10.1016/j.jdiacomp.2015.01.010. PubMed PMID: 25784088; PubMed Central PMCID: PMC4414902. 

  40. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ Jr, Meléndez LM. HIV gp120 sequence variability associated with HAND in Hispanic Women. J Virol Antivir Res. 2015;4(3). pii: 143. PubMed PMID: 27358904; PubMed Central PMCID: PMC4922650. 

  41. Ortiz-Martínez MG, Rodríguez-Cotto RI, Ortiz-Rivera MA, Pluguez- Turull CW, Jiménez-Vélez BD. Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico. Mediators Inflamm. 2015;2015:784212. doi: 10.1155/2015/784212. PubMed PMID: 26681839; PubMed Central PMCID: PMC4670654. 

  42. Rivera-Díaz M, Miranda-Román MA, Soto D, Quintero-Aguilo M, Ortiz-Zuazaga H, Marcos-Martinez MJ, Vivas-Mejía PE. MicroRNA- 27a distinguishes glioblastoma multiforme from diffuse and anaplastic astrocytomas and has prognostic value. Am J Cancer Res. 2014 Dec 15;5(1):201-18. PubMed PMID: 25628931; PubMed Central PMCID: PMC4300691. 

  43. Martínez O, Miranda E, Ramírez M, Santos S, Rivera C, Vázquez L, Sánchez T, Tremblay RL, Ríos-Olivares E, Otero M. Immunomodulator-based enhancement of anti smallpox immune responses. PLoS One. 2015 Apr 13;10(4):e0123113. doi: 10.1371/journal.pone.0123113. PubMed PMID: 25875833; PubMed Central PMCID: PMC4395221. 

  44. Otero M, Zayas B, Miranda E, Velez C, Hernandez WJ, Rivera LA, Cox O. Immunomodulatory Response Triggered by the Alkaloids, 3- Amino-7-Benzylbenzimidazo[3,2-a] Quinolinium Chloride (ABQ-48) and 3-Nitro-7-Benzylbenzimidazo [3,2-a] Quinolinium Chloride (NBQ-48). J Cancer Res Ther Oncol. 2015 May 4;1. doi: 10.17303/jcrto.2015.103. PubMed PMID: 26086027; PubMed Central PMCID: PMC4467908. 

  45. Estape ES, Torres-Negron I, Gonzalez L, Martinez-Maldonado M. A New Animal Model to Study Endogenous Cardiotonic Steroids and the Progression of Cardiovascular Events in Salt-Sensitive Hypertension. Int Arch Transl Med. 2015;1(1). pii: 002. PubMed PMID: 26457335; PubMed Central PMCID: PMC4599712. 

  46. Torres-Hernández BA, Del Valle-Mojica LM, Ortíz JG. Valerenic acid and Valeriana officinalis extracts delay onset of Pentylenetetrazole (PTZ)-Induced seizures in adult Danio rerio (Zebrafish). BMC Complement Altern Med. 2015 Jul 14;15:228. doi: 10.1186/s12906-015-0731-3. PubMed PMID: 26168917; PubMed Central PMCID: PMC4501072. 

  47. Elías-Boneta AR, Toro MJ, Garcia O, Torres R, Palacios C. High prevalence of overweight and obesity among a representative sample of Puerto Rican children. BMC Public Health. 2015 Mar 5;15:219. doi: 10.1186/s12889-015-1549-0. PubMed PMID: 25885462; PubMed Central PMCID: PMC4358900. 

  48. Martínez T, Ropelewski AJ, González-Mendez R, Vázquez GJ, Robledo IE. Draft Genome Sequence of Klebsiella pneumoniae Carbapenemase-Producing Acinetobacter baumannii Strain M3AC9-7, Isolated from Puerto Rico. Genome Announc. 2015 Apr 9;3(2). pii: e00274-15. doi: 10.1128/genomeA.00274-15. PubMed PMID: 25858845; PubMed Central PMCID: PMC4392157. 

  49. Rosa-Falero C, Torres-Rodríguez S, Jordán C, Licier R, Santiago Y, Toledo Z, Santiago M, Serrano K, Sosa J, Ortiz JG. Citrus aurantium increases seizure latency to PTZ induced seizures in zebrafish thru NMDA and mGluR's I and II. Front Pharmacol. 2015 Feb 13;5:284. doi: 10.3389/fphar.2014.00284. PubMed PMID: 25762932; PubMed Central PMCID: PMC4327740. 

  50. Soto R, Guilloty N, Anzalota L, Rosario Z, Cordero JF, Palacios C. Association between maternal diet factors and hemoglobin levels, glucose tolerance, blood pressure and gestational age in a Hispanic population. Arch Latinoam Nutr. 2015 Jun;65(2):86-96. PubMed PMID: 26817380; PubMed Central PMCID: PMC5324707. 

  51. Castillo-Pichardo L, Dharmawardhane S, Rodríguez-Orengo JF. Rapid quantification of resveratrol in mouse plasma by ultra high pressure liquid chromatography (UPLC) coupled to tandem mass spectrometry. P R Health Sci J. 2014 Dec;33(4):151-6. PubMed PMID: 25563031.