The mission of the RCMI Translational Proteomics Center (TPC) is to significantly enhance the current capacity for biomedical research at the UPR-MSC. Loyda M. Meléndez, PhD, currently serves as Director, of the Proteomics Service (PS) and Lead of the Research Infrastructure Core.
The Proteomics Service functions as a platform for biomarker discovery and protein identification and as an interface between basic and clinical research conducted in Puerto Rico for the diagnosis and therapeutic monitoring of human diseases. This core facility provides resources and expertise in Proteomics to scientists in the two other RCMI programs in Puerto Rico (Ponce School of Medicine, and Universidad Central del Caribe), partner institutions in the PRINBRE Program, and other campuses of the UPR System. The facility is equipped with a LTQ XL MS/MS. This is the backbone of the proteomics platform for the rapid discovery of multiple biomarkers and for protein identification. Recently, the PR-INBRE Program approved funds to acquire a Thermo Scientific™ Q Exactive™ Hybrid Quadrupole Orbitrap Mass Spectrometer. Current studies supported by the TPC include:
- A genomic approach to warfarin dose prescription in admixed Caribbean Hispanics (SC1HL123911);
- Endocytic mechanisms controlling functional selectivity of the CB1R (R01DA037924);
- Exosome-mediated soluble insulin receptor secretion correlates with HAND (R01NS099036), and Molecular targets of soy isoflavones in breast cancer progression (SC3GM084824).
The TPC and GTRU share a license for the Ingenuity Pathway Analysis platform for network, canonical pathways, and other types of system biology analyses, and to assist in the identification of new targets or candidate biomarkers.
Yadira M. Cantres, BS