Research Advancement in Mitochondrial Research: Dr. Sabzali Javadov
Article Title: Elucidating mitochondrial ETC supercomplexes in the heart during ischemia-reperfusion
Institution and State: Department of Physiology, School of Medicine, University of Puerto Rico Medical Sciences Campus, San Juan Puerto Rico
Senior Author: Sabzali Javadov, Ph.D.
The results of collaborative research lead by Dr. Sabzali Javadov, Professor of the Department of Physiology, UPR School of Medicine have been accepted for publication in Antioxidants and Redox Signaling with an impact factor (IF) of 7.1. A team of scientists from Dr. Javadov’s laboratory in collaboration with the laboratories of Dr. Peter Wipf’s (University of Pittsburgh, Pittsburgh, PA), Dr. Zaza Khuchua’s (Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH) and Dr. Christopher Baines’s (University of Missouri-Columbia, Columbia, MO) elucidated the role of mitochondrial supercomplexes, large supramolecular assemblies of individual electron transport chain (ETC) complexes in the animal model of myocardial infarction. The findings of the study established a causative role of mitochondrial permeability transition-induced reactive oxygen species in disassembly of ETC supercomplexes that was confirmed using the recently developed mitochondria-targeted antioxidant XJB-5-131. The study is important for understanding of molecular mechanisms of mitochondrial dysfunction and alterations of energy metabolism in response to oxidative stress induced by myocardial infarction (ischemia-reperfusion).
Jang S, Lewis TS, Powers C, Khuchua Z, Baines CP, Wipf P, Javadov S. Elucidating mitochondrial ETC supercomplexes in the heart during ischemia-reperfusion. Antioxid Redox Signal. 2016 Sep 7. [Epub ahead of print] PMID: 27604998 DOI:10.1089/ars.2016.6635