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School of Pharmacy

  1. Antoun, Mikhail, Ph.D. (Professor) Director,
    "Department of Pharmaceutical Sciences"
    e-mail:mantoun@rcm.upr.edu

    Investigation of natural products for bioactive compounds, specifically anti-HIV, anticancer and antimalarials.

  2. Bloom, Joseph, Ph.D. (Assistant Professor)
    e-mail:jbloom@rcm.upr.edu
    My research interest is in the application of HPLC/MS/MS using atmospheric pressure ionization or electrospray ionization for the determination of inborn errors of metabolism or metabolic disorders in neonates and children. Some biomarkers used to determine these metabolic disorders are the analysis of acylcarnitines, fatty acids, and endogenous compounds related to organic acidemias. This could be done in the blood or urine. Also, the analysis of organic acidemias can be carried out using GC/MS.
    The use of capillary electrophoresis (CE) for the analysis of the compounds mentioned above is another area of interest. Another resrach area is the application of EC in different areas of the pharmaceutical industry such as quality control and quality assurance, method validation, and others.
    Application of GC/MS and CE for the therapeutic monitoring of drugs through hair analysis is another area of interest. Pharmacokinetics of the anesthetic propofol in our population is a research project of great interest because it can e the beginning of drug monitoring due to ethnic differences.

  3. Vlaar Cornelis P., Ph.D. (Assistant Professor)
    e-mail:cvlaar@rcm.upr.edu
    Dr. Vlaar’s research is directed towards the continued synthesis of potential novel inhibitors of dihydroorotate dehydrogenase (=DHODH). DHODH is a well-defined target enzyme that plays a key role in the biosynthesis of pyrimidine nucleotides. Since proliferating cells have a high demand for pyrimidine nucleotides, inhibition of DHODH is a valuable means to halt cell proliferation.
    A major focus of the research is the discovery and development of inhibitors that will selectively inhibit Plasmodium falciparum DHODH and not human DHODH (collaboration with Dr. G. McConkey, Leeds University and Dr. J. Clardy, Harvard Medical School). Potentially, via development of novel selective inhibitors, the proliferation of the malaria parasites can be halted, while the compounds will exhibit only reduced possibilities of side effects. The same compounds also will be tested for inhibitory activity against Toxoplasmosis Gondii-DHODH.

  4. Ghaly, Evone S., Ph.D. (Professor)
    e-mail:eghaly@rcm.upr.edu

    My research interests are focused in drug delivery systems, such as development of the most feasible approach for controlling drug release and targetting its delivery to a specific site in the body. Also I am interested in solid dosage forms, physics of compaction and compaction characterization of different systems. Knowledge of much of consolidation of substances intended for pharmaceutical use offer considerable information of value in the development of tablets. Other areas include better understanding of Granulation in order to optimize agglomeration process and to understand mechanism of granule growth, enhancing dissolution (in vitro and in vivo bioavailability), sphermization complexation and protein binding.

  5. Guerrero, Ricardo O., Ph.D. (Professor)
    e-mail:rguerrero@rcm.upr.edu

    I am working on isolation and structural characteristics of biological active compounds from plants. I am also screening extracts from higher plants of Puerto Rico and the Amazon basin for biological activities, especially enzymatic inhibitions.

  6. Hernández, Lesbia, Pharm.D, M.P.H., R.P.H. (Professor)
    e-mail:lhernandez@rcm.upr.edu

    My research interests include the cancer pain management, acute pain management, cancer related fatigue, health related quality of life.

  7. Hine, Bromfield, Ph.D. (Professor)
    e-mail:ahine@rcm.upr.edu

    My research program is in the general area of pre-clinical psychopharmacology and behavioral neuroscience. One goal is to develop a better understanding of brain mechanisms involved in addictive behavior. More specifically, I am studying whether or not different classes of abused drugs, especially opiates, alcohol and marijuana derivatives, affect neural pathways that appear to be involved in hedonic experiences in a similar manner. Various procedures are used, including brain stimulation reward techniques, and evaluation of drug self-administration procedures in rats.

    Presently, I am concentrating on alcohol, examining variables that influence drinking behavior in genetically-selected rat lines differing in sensitivity to alcohol’s intoxicating effects. The role of opioids in alcoholism in these lines is a major area of interest.

  8. Lugo, Sonia I., Ph.D. (Associate Professor)
    e-mail:slugo@rcm.upr.edu

    I am studying the use of mathematical models to characterize the pharmacokinetics and pharmadynamics of drugs. I have been involved in studies dealing with the effect of exercise, sleep deprivation, altitude and stereoisomerism on pharmacokinetics and pharmacodynamics of drugs such as caffeine, ICG and others. The development of closed-loop systems for the administration of neuromuscular blocking agents during anesthesia is another area of interest.

  9. Maldonado, Wanda T, Pharm.D. (Professor)
    e-mail:wmaldonado@rcm.upr.edu

    Dr. Maldonado’s research is related to pharmacodynamics and pharmacokinetics of Anti-infective agents. She is also interested in describing patterns of safety, tolerance and response to antimicrobials in our population.

  10. Martí, Arturo, Ph.D. (Professor) Director, Chemical Forensic Laboratories
    e-mail:amarti@rcm.upr.edu

    Research work in our laboratory centers around analytical methods used to identify drugs or their metabolites:
  1. Disposition and metabolism of controlled substances;
  2. Disposition and metabolism of steroids and their metabolites in the CNS in Clinical settings.
  1. Miranda Massiri, Jorge, Ph.D. (Assistant Professor)
    e-mail:jmiranda@rcm.upr.edu

    MAJOR RESEARCH/PROFESSIONAL INTEREST
  1. Non-toxic Therapies for Solid Tumors using biological response modifiers
  2. Pharmacokinetics of Hispanic population.
  3. Phytomedicinals and other Dietary Supplements for Chronic Diseases
RECNAC II is a research initiative aimed to the development of effective, non-toxic cancer treatments. Our ultimate goal is to develop a protocol that will revert the cancer process in our lifetime.
  1. Monsanto, Homero A., Ph.D. (Professor)
    e-mail:hmonsanto@rcm.upr.edu

    Current research interest and expertise are in the area of development and implementation of pharmaceutical care practice models, the documentation and evaluation of outcomes (clinical, economic and humanistic) associated with the use of medications and pharmacists’ interventions and the evaluation of public policies pertaining to the use of medications and pharmaceutical services.

Back to Research Interests Main Page
Contact:
Emma Fernández-Repollet,Ph.D.
Program Director
RCMI Program
Room 621-A, 6th. floor
Main Building, Medical Sciences Campus
GPO Box 365067
San Juan, PR 00936-5067
Email: efernandez@rcm.upr.edu
Telephones:
Voice (787) 763-9401
FAX (787) 758-5206


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