Transmission of Endoscopic Procedures from the Medical Sciences Campus to Four Institutions Simultaneously
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Department of Pathology
- Climent, Consuelo, M.D. (Associate Professor)
e-mail:pitirre@ASEM.net
- Evaluation of the Coagulation Function of N-linked Glycosylation of Blood Coagulation Factor VIII:C from Mild and Moderate Classic Hemophiliacs, Their Carrier Mothers, and a Control Group.
- Unexcepted Red Blood Antibody Frequency in the Puerto Rico Medical Center Patient Population and donors of the Blood Center of the American Red Cross.
- Seroprevalence of Cytomegalovirus antibodies in Puerto Rican Blood Donors.
- Hillyer, George V., Ph.D. (Professor)
e-mail:ghillyer@rcm.upr.edu
The Laboratory of Parasite Immunology and Pathology (LPIP) at the Department of Pathology, Laboratory and Laboratory Medicine (Suite 617-A), UPR School of Medicine focuses on research and research training in the areas of:
- Molecular parasitology;
- Immune responses in parasitic infections with emphasis on fascioliasis and schistosomiasis;
- Clinical immunology and virology with emphasis on HIV;
- Minority International Research Training in Molecular Biology and Infectious Disease.
- The molecular parasitology component focuses primarily on two parasitic trematodes: Fasciola hepatica and Schistosoma mansoni. Fasciola hepatica is a parasitic trematode, commonly known as the liver fluke, which infects primarily sheep, cattle, and humans. Our research seeks to define the proteins that are sequentially expressed on the surface of the fluke during "early" development following infection of the mammalian host; i.e. the proteins expressed during the change from the cystic metacercaria to the juvenile worm. The generation of cDNA probes specific for these molecules will provide a handle to examine the genes involved and enable the study of the regulation of their expression during the parasite's life cycle. Among genes being studied are
those encoding fatty acid binding proteins (FABPs), glutathione S-transferase (FhGST), and an amoebapore-like lytic protein. The FABPs have been found to be a complex of over 7 isoforms with approximately 40 fatty acids binding to them. The native Fasciola FABP cross-reacts with S. mansoni
and is a cross protective antigen with veterinary and human vaccine potential. Chemical studies on the fatty acids are in collaboration with Dr. Nestor Carballeira from the UPR Río Piedras Campus.
Studies on immune responses are to identify purified and recombinant molecules with potential for the early and specific immunodiagnostic detection of infections in schistosomiasis and fascioliasis in humans and animals.
Clinical immunology and virology ioncludes the Women and Infants Transmission Study, the UPR-AIDS Clinical Trials Unit - Pediatrics, the UPR-AIDS Clinical Trials Unit-Adults, and the AIDS Clinical Trials Group (ACTG) of which our laboratory in #055 for HIV immunology and virology, all sponsored by the NIH-NIAID.
The UPR-MIRT Program offers an opportunity for undergraduate and graduate students at UPR Río Piedras and Medical Sciences Campus to participate in collaborative research related to the broad area of international health problems focusing around molecular and immunological aspects of tropical medicine and parasitology. The areas include infectious diseases, cell biology, molecular biology, parasitology, and field biology. The objective of the program is to learn through research and to encourage and facilitate access and successful completion of graduate studies by students via faculty at UPR Río Piedras and Medical Sciences Campus doing collaborative research with investigators and faculty at research institutes and universities in Australia and Europe including the UK, Germany, Switzerland, France, and Spain. Current University of Puerto Rico faculty are from departments of Pathology and Lab. Med., Biochemistry, Physiology, and Biology.
These two, AIDS Clinical Trails Unit - Adults, and the AIDS Clinical Trials Unit-Pediatrics, are supported by the National Institutes of Allergy and Infectious Diseases.
- Vélez Rosario, Román, M.D. (Professor)
e-mail:pitirre1@ASEM.net
- Evaluation of the Coagulation Function of N-linked Glycosylation of Blood Coagulation Factor VIII:C from Mild and Moderate Classic Hemophiliacs, Their Carrier Mothers, and a Control Group.
- Unexcepted Red Blood Cell Antibodies in the Puerto Rico Medical Center Patient Population and donors of the Blood Center of the American Red Cross.
- Seroprevalence of Cytomegalovirus antibodies in Puerto Rican Blood Donors.
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Contact:
- Emma Fernández-Repollet,Ph.D.
- Program Director
- RCMI Program
- Room 621-A, 6th. floor
- Main Building, Medical Sciences Campus
- GPO Box 365067
- San Juan, PR 00936-5067
- Email: efernandez@rcm.upr.edu
- Voice (787) 763-9401
- FAX (787) 758-5206
